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In medical, psychological, sociological, and educational studies, researchers often design experiments in which they collect baseline (pretest) data prior to randomization. However, they often find it difficult to decide which method of statistical analysis is most appropriate to use. Analysis of Pretest-Posttest Designs brings welcome relief from

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These volumes are designed to be the most complete guide to pharmacokinetics (PK) and its role in drug development. The volumes fill a gap between the academic science and the practical application of that knowledge in drug development. Volume 1 discusses the role that PK plays in selected clinical study designs. Volume 2 details the key regulatory and development paradigms in which PK supplements decision-making during drug development.

Since its publication in 2006, Pharmacokinetic-Pharmacodynamic Modeling and Simulation has become the leading text on modeling of pharmacokinetic and pharmacodynamic data using nonlinear mixed effects models and has been applauded by students and teachers for its readability and exposition of complex statistical topics. Using a building block approach, the text starts with linear regression, nonlinear regression, and variance models at the ind...

Since its publication in 2006, Pharmacokinetic-Pharmacodynamic Modeling and Simulation has become the leading text on modeling of pharmacokinetic and pharmacodynamic data using nonlinear mixed effects models and has been applauded by students and teachers for its readability and exposition of complex statistical topics. Using a building block approach, the text starts with linear regression, nonlinear regression, and variance models at the ind...

Helps clear the confusion about analyzing pretest-posttest data. This work also helps to understand the pros and cons of different methods - ANOVA, ANCOVA, percent change, and difference scores and learn to choose the appropriate statistical test. It gathers and elucidates the concepts and techniques useful for studies incorporating baseline data.

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